منابع مشابه
Clarifying the cardiac proteasome paradox: protein quality control.
Correct folding of proteins is crucial for proper protein, cell, and organ function.1 Mutations and cellular stresses, some of which occur during pathology, can lead to incorrect folding and subsequent loss of protein function. If it goes uncorrected, then this loss of protein function, along with the toxicity associated with the accumulation of misfolded proteins in cells, results in eventual ...
متن کاملThe cardiac 26S proteasome: regulating the regulator.
Significance of Ubiquitin–Proteasome– Mediated Degradation of Proteins The ubiquitin–proteasome system (UPS) is the main pathway for the nonlysosomal degradation of intracellular proteins, representing upwards of 80% of all intracellular proteins. A key component of the UPS is the 26S proteasome, a macromolecular multisubunit complex that has the responsibility of recognizing, unfolding, and th...
متن کاملMapping the murine cardiac 26S proteasome complexes.
The importance of proteasomes in governing the intracellular protein degradation process has been increasingly recognized. Recent investigations indicate that proteasome complexes may exist in a species- and cell-type-specific fashion. To date, despite evidence linking impaired protein degradation to cardiac disease phenotypes, virtually nothing is known regarding the molecular composition, fun...
متن کاملThe ubiquitin-proteasome system in cardiac dysfunction.
Since proteins play crucial roles in all biological processes, the finely tuned equilibrium between their synthesis and degradation regulates cellular homeostasis. Controlling the quality of proteome informational content is essential for cell survival and function. After initial synthesis, membrane and secretory proteins are modified, folded, and assembled in the endoplasmic reticulum, whereas...
متن کاملParadox of cardiac arrhythmia in anaesthesia.
Methylphinidate, un stimulant psychomoteur a faible action sympathomime'tique, supprime completement la spasticite' musculaire ct le tremblement, qui peuvent se manifester au cours du rttablissement d'une anesthesie a liialothane. Lcs auteurs croient que la spasticuS est due au re'tablissement de l'activirf spinale reftexe, qui precede celfc dcs neurones moteurs supirieurs, de l'inhibitkm par l...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2012
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.112.275917